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Where we Began
What if the human proteome were larger than we imagined?
Twenty years ago, the Human Genome Project concluded that the human proteome is comprised of only about 20,000 protein-coding genes based on a discrete set of rules. We asked, ‘What if we broke the bounds of these rules and the human proteome were considerably larger than previously believed?’ If this were true, it would represent a paradigm shift in biology and reveal a universe of novel therapeutic protein drugs and drug targets.
By applying novel technologies to identify the full set of proteins translated by human ribosomes, together with the application of high throughput biological assessment to uncover their functional roles in health and disease, we have found tens of thousands of undiscovered proteins that could provide important new intervention points across many diseases, opening a whole new world of therapeutic possibilities.
Our Approach
A new universe of possibilities
We have discovered a vast, expanded universe of novel proteins encoded by the human genome. In analyzing these proteins, we elucidate their respective biological functions, refining our understanding of the molecular underpinnings of human biology and disease. Armed with this knowledge, we’re aiming to create breakthrough medicines for a multitude of diseases.
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